By Andrew Young
Deciphers amylin's body structure and divulges formerly unrecognized mechanisms basic to regulate bodyweight and gas homeostasis. additionally discusses healing software of amylin because the first new drugs to regard diabetes considering that insulin.
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Additional resources for Amylin: Physiology and Pharmacology
And Beaumont, K. (1996). Preclinical pharmacology of pramlintide in the rat: Comparisons with human and rat amylin. Drug Dev. Res. 37, 231–248. Zweers, E. J. , van Hulst, K. , Lips, C. J. , Christiaens, G. C. M. , Hackeng, W. H. , and Erkelens, D. W. (1992). Glucose stimulated islet amyloid polypeptide and gestational diabetes mellitus. Diabetologia 35, A179. Andrew Young Receptor Pharmacology I. Summary ____________________________________________________________________________________________________________________ Despite clear evidence for a distinct amylin pharmacology and localization of such pharmacology to sites such as the nucleus accumbens, efforts to clone an amylin receptor were fruitless for over a decade.
J. Cardiovasc. Pharmacol. 16(suppl. 4), S60–S64. Young, A. , Rink, T. , and Wang, M. W. (1993). Dose response characteristics for the hyperglycemic, hyperlactemic, hypotensive and hypocalcemic actions of amylin and calcitonin gene‐related peptide‐I (CGRP‐alpha) in the fasted, anaesthetized rat. Life Sci. 52, 1717–1726. Tissue Expression and Secretion of Amylin 45 Young, A. , and Rink, T. J. (1995). Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin.
In human type 2 diabetes, fasting and stimulated plasma amylin concentrations are generally lower in those treated with insulin (typically exhibiting greater b‐cell failure) than in those treated with oral hypoglycemic agents. , 1993). , 1996). H. , 1966). , 1996), another condition associated with insulin resistance. , 1992). In this case, however, the elevation likely reflects reduced renal amylin clearance in those patients rather than increased secretion. , 1996, 1998), indicating a major role for the kidney in clearance of circulating amylin.
Amylin: Physiology and Pharmacology by Andrew Young