By Jeffrey L Cummings, Serge Gauthier
Given the improvement of recent healing ideas and items, Serge Gauthier and Jeffrey Cummings have compiled an inventory of up to date themes so one can be of curiosity essentially to neurologists targeting Alzheimer's disorder, and in addition to psychiatrists and geriatricians. The individuals, all revered of their subspecialties, have written updated, comprehensively referenced chapters which should offer information in addition to stimulate dialogue on the place present remedy is heading.
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Extra resources for Alzheimer's disease and related disorders annual, 2002
15. Gervais FG, Thornberry NA, Ruffolo SC et al. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. J Biol Chem 1998; 273: 17102–17108. 16. Milligan CE. Caspase cleavage of APP results in a cytotoxic proteolytic peptide. Nat Med 2000; 6:385– 386. 17. Clem RJ, Sheu TT, Richter BW et al. c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. J Biol Chem 2001; 276:7602–7608. 18. Deveraux QL, Leo E, Stennicke HR et al. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
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In the case of caspases, the issue is complicated because these proteins are produced as zymogens that must be cleaved to become active. Once activated, other molecules in the cell can still inhibit the caspase activity. The presence of active caspase fragments, either detected in the cell by immunohistochemistry or in homogenates by cleavage of fluorogenic substrates, has often been accepted as evidence that a cell is undergoing apoptosis and as evidence that the detected caspase is playing a crucial role in the death pathway.
Alzheimer's disease and related disorders annual, 2002 by Jeffrey L Cummings, Serge Gauthier