By Robert Katzman, Katherine Bick
authors are imminently certified to put in writing in this subject...their first-hand wisdom of the interval in query and of the participants they interview enriches the book's content material considerably.''
--Norman R. Relkin, MD, PhD in NEUROLOGY (April 2001)
''Katzman and Bick show massive interviewing talents, and their respondents supply remarkably beneficiant and candid fabric. This publication will for this reason fascinate scholars of the background of technology, despite their curiosity in Alzheimer's affliction. if you happen to have such curiosity, it's a infrequent treat.''
--John C.S. Breitner, MD, MPH, ANNALS OF NEUROLOGY (March 2001)
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Additional resources for Alzheimer Disease. The Changing View
RK: Did you shov^ him electron micrographs, comparing early and later RT: I think that by then most of us in the field believed that this was an artificial distinction. RK: Even the pathologists? RT: Yes, those few ^vho w^ere thinking about Alzheimer's disease. RK: So as far as you remember, you pointed this out in response to a question from Martin Roth in 1965? 28 RT: 2. T H E PIONEERS H e also asked whether the plaques of the normal patient were any different from the plaques in the Alzheimer patient and I told him, perhaps wrongly, that I could not see any differences in the plaques but we had not seen that many plaques in the normals since we didn't do biopsies on normals.
Thomas's. During my clinical years, the most profound and lasting impression was created by George Pickering. He was the youthful, newly elected professor, a product of the famous school of clinical science, Avhich had evolved in University College (London) under Sir Thomas Lewis between the ^vars. H e was perhaps Lewis' most brilliant pupil. MARTIN ROTH 49 He brought intellectual precision of thought and inference and indeed the essentials of a scientific investigative approach to medicine. His pupils were in the next few decades to fill most of the important chairs of medicine in the British Isles and in outposts of empire such as Australia and Canada.
Well, in the late 1960s we got some old dogs and some old monkeys. We saw plaques, long before Don Price did, 10 or 15 years before. Sue Donahue had an ancient retriever of some sort and we looked at it together. There were plaques but no PHF. Whereas in the monkey we did see a very few PHF. RK: Bob, as I look back on our long association and the puzzle that is AD, It IS apparent that your willingness to tackle its ultrastructure, with all the problems of electron microscopy in the early days, opened up the modern approaches to the disease.
Alzheimer Disease. The Changing View by Robert Katzman, Katherine Bick