By Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons
This booklet stories the pathophysiology and actual manifestations of acromegaly and discusses the a number of therapies now on hand for the administration of the sufferer with acromegaly. The publication includes an considerable variety of illustrations that aid to stress issues of specific curiosity, together with radiological, histopathological, and actual analysis photographs. Sections are dedicated to detailing very important subject matters together with determinants of pathological results of illness job in acromegaly, person healing offerings and standards for analysis, and ailment regulate.
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Extra resources for Acromegaly: Pathology, Diagnosis and Treatment
Wien Klin Wochenschr 1907; 20:621–624. 23. Artico M, Pastore FS, Fraioli B, Giuffre´ R. The contributions of Davide Giordano (1864–1954) to pituitary surgery: the transglabellar–nasal approach. Neurosurgery 1998; 42:909–912. 24. Kocher T. Ein Fall von Hypophysis-tumor mit operativer Heilung. Dtsch Z Chir 1909; 100:13–37. 25. Cushing H. Partial hypophysectomy for acromegaly; with remarks on the function of the hypophysis. Ann Surg 1909; 50:1002–1017. 26. Liu JK, Das K, Weiss MH, Laws ER, Couldwell WT.
PAS orange stain) Source: J. Trouillas 3. Epidemiology, Pathology, and Complications 43 One of the more frequent subclassifications of GH-secreting pituitary tumors divides tumors by intracellular granule number into densely granulated and sparsely granulated adenomas (Figs. 3–6). These two morphological types differ in their clinical behavior, with sparsely granulated tumors more likely to be macroadenomas, to have a higher rate of extension and/or invasiveness, and to have poorer responses to somatostatin analogs (21).
Acromegaly and pituitary tumors: early anatomoclinical observations. Surg Neurol 1995; 44:83–87. 9. Fritsche CF, Klebs TAE. Ein Beitrag zur Pathologie des Riesenwuchs. In: Klinische und pathologischananatomische Untersuchungen. Leipzig: Vogel, 1884. 10. Marie P. Sur deux cas d’acromegalie: hypertrophie singule´re non congenitale des extre´mitie´s supe´rieures, infe´rieures et ce´phalique. Rev Med 1886; 6:297–333. ¨ ber einen Fall von Akromegalie. Berl Klin Wochensch 1887; 11. Minkowski O. U 21:371–374.
Acromegaly: Pathology, Diagnosis and Treatment by Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons