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Get A Practical Guide to Diabetes Mellitus PDF

By Nihal, Thomas; Nitin, Kapoor, Jachin Velavan, Senthil Vasan,

ISBN-10: 9351528537

ISBN-13: 9789351528531

A realistic consultant to Diabetes Mellitus is the newest variation of this complete, hugely illustrated consultant to diabetes. The publication is constituted of 30 chapters, encompassing various functional remedies for diabetes. starting with an outline of the anatomy and body structure of the pancreas, next chapters conceal issues equivalent to scientific meals treatment, insulin treatment, diabetic foot, and ocular disorder. This version comprises fresh chapters on weight problems, wound care, the aged and epidemiology. The bankruptcy on insulin treatment outlines key points of insulin injection suggestions, blending of insulin, and websites for insulin management. This revised and more desirable variation of a pragmatic advisor to Diabetes Mellitus is better by means of 136 complete color photos and illustrations, making it an excellent spouse for all scholars and practitioners of diabetology, and basic physicians. Key issues * most up-to-date variation of finished advisor to diabetes * earlier variation released 2012 (9789350259672) * New chapters on weight problems, wound care, the aged, and epidemiology *136 complete color photos and illustrations

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Additional resources for A Practical Guide to Diabetes Mellitus

Example text

In the absence of insulin, the FFA levels greatly increase. The FFA is catabolized to acetyl CoA in the liver and other tissues and the excess acetyl CoA is converted to form ketone bodies. Consequences of Disturbed Protein Metabolism There is decreased protein synthesis and increased protein breakdown leading to protein catabolism and muscle wasting. There is increased plasma amino acids and nitrogen loss in urine. All this leads to negative nitrogen balance and protein depletion. Protein depletion causes poor resistance to infections.

It increases the sensitivity to insulin, suppresses glucagon secretion by the α cells, slows down the process of gastric emptying, increases glucose disposal and reduces quantity of food intake. GLP-1 infusion has a glucose lowering effect in type 2 diabetic patients, and there is a rapid rise in blood glucose levels after termination of the GLP-1 infusion. 9 10 A Practical Guide to Diabetes Mellitus Fig. 9: The impact and actions of glucagon-like peptide-1 (GLP-1). Source: Adapted from Kieffer & Habener (1999): Endocrine Reviews GLP-1 in the Pancreas: Insulin Secretion and β cell Mass GLP-1 rapidly and potently stimulates insulin secretion.

Insulin Receptor Insulin receptors are present in almost all cells of the body. It is a glycoprotein made of 2α and 2β subunits linked by disulfide bridges (Fig. 3). The α subunit which binds insulin is extracellular, while the β subunit extends from the cell membrane into the cell. The part of the β subunit, which extends into the cell has tyrosine kinase activity. The number and affinity of insulin receptors is affected by various factors like insulin levels, exercise and food. An increased concentration of insulin decreases the number of insulin receptors called downregulation and decreased concentrations of insulin increases the affinity of the insulin receptors.

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A Practical Guide to Diabetes Mellitus by Nihal, Thomas; Nitin, Kapoor, Jachin Velavan, Senthil Vasan,


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